Yes, Anthony Weiner can make a political comeback.

Hope you can join me tomorrow morning (Thursday) at 9:25 AM on Curtis Sliwa's radio show discussing Anothony Weiner. He has already started his comeback. http://www.am970theanswer.com/
Weiner may never be mayor, but he can be an effective NYC Public Advocate, and once elected Advocate, anything can happen in the world of politics.  Look at Bill Clinton.  Clinton is one of the most beloved figures in the world.

Here's the NY Times take on Weiner in People Magazine. Here is how even the Mail in England is playing the situation.